A potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM). Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake. Elevates CSF tryptophan by up to 260% and CSF serotonin by 170% of basal. TDO inhibition by 680C91 in glioma...
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A potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM). Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake. Elevates CSF tryptophan by up to 260% and CSF serotonin by 170% of basal. TDO inhibition by 680C91 in glioma cells blocked the release of kynurenine, an endogenous tumor promoting AHR ligand
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