A metabolically stable adenosine analog that acts as an agonist at A1, A2a, and A3 adenosine receptors (Ki = 300, 80, 1900 nM). 2-Chloroadenosine is also a bidirectional substrate for equilibrative nucleoside transporter 4 (ENT4) in acidic conditions. At 100 µM, it causes accumulation of cAMP in...
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A metabolically stable adenosine analog that acts as an agonist at A1, A2a, and A3 adenosine receptors (Ki = 300, 80, 1900 nM). 2-Chloroadenosine is also a bidirectional substrate for equilibrative nucleoside transporter 4 (ENT4) in acidic conditions. At 100 µM, it causes accumulation of cAMP in neonatal mouse osteoblast-like cells. Reduces intracellular ATP levels through both ATP consumption and AMP deamination, and induces apoptosis in leukemic B-cells and rheumatoid fibroblasts
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