Stat1 polyclonal antibody; host Rabbit; reactivity Human, Mouse, Rat
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signal transducer and activator of transcription 1(STAT1) Homo sapiens The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | IF/ICC | WB | IHC-P | IP | ELISA |
|---|---|---|---|---|---|
| Human,Mouse,Rat |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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STAT1 identifies signal transducer and activator of transcription 1 in Homo sapiens (Human). This target record connects NCBI Gene 6772, UniProtKB P42224 and related ABMIUM catalogue products.
Biological function: Signal transducer and activator of transcription 1 (STAT1; STAT91) is a cytokine-activated transcription factor central to interferon signalling. Following JAK-dependent phosphorylation, STAT1 forms transcriptional complexes that regulate antiviral, antimicrobial and immune-response genes.
