SIRT5 polyclonal antibody; host Rabbit; reactivity Human, Mouse, Rat
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NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically
removes malonyl, succinyl and glutaryl groups on target proteins . Activates CPS1 and
contributes to the regulation of blood ammonia levels during prolonged fasting: acts by
mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting . Activates SOD1 by mediating its
desuccinylation, leading to reduced reactive oxygen species . Activates SHMT2 by
mediating its desuccinylation . Modulates ketogenesis through the desuccinylation and
activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase
activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB |
|---|---|
| Human,Mouse,Rat |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
