CREB-2 polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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activating transcription factor 4(ATF4) Homo sapiens This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provid
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | IHC-P | IF | ELISA |
|---|---|---|---|---|
| Human,Rat,Mouse |
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Activating transcription factor 2 (ATF2), also known as CREB-2 and cyclic AMP-dependent transcription factor ATF-2, is a bZIP transcription factor that integrates CRE/AP-1 transcription with cellular stress and DNA-damage responses. Human ATF2 maps to NCBI Gene 1386 and reviewed UniProtKB P15336; this record links the verified target to related ABMIUM catalogue products.
Biological function: ATF2 is a transcriptional activator that binds CRE or AP-1 response elements depending on its dimerization partner. Curated annotations support roles in gene-expression control and DNA-damage responses, with stress-regulated transcriptional activity and subcellular localization.
