ApoC-III polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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apolipoprotein C3(APOC3) Homo sapiens Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | IHC-P | IF | ELISA |
|---|---|---|---|---|
| Human,Rat,Mouse |
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APOC3 (apolipoprotein C3) encodes apolipoprotein C-III (ApoC-III), a component of triglyceride-rich lipoproteins including VLDL and chylomicrons and also of HDL. APOC3 is a key regulator of triglyceride homeostasis through effects on lipoprotein production, lipolysis and remnant clearance.
Biological function: Apolipoprotein C-III regulates triglyceride-rich lipoprotein metabolism at several steps. NCBI and reviewed UniProt describe APOC3 as promoting hepatic VLDL1 assembly and secretion, inhibiting lipoprotein lipase-mediated triglyceride hydrolysis, and delaying hepatic clearance of triglyceride-rich lipoprotein remnants.
