NEDD4L (phospho-Ser448) antibody from Promab.
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NEDD4L is an E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signalling pathways including autophagy, innate immunity or DNA repair. NEDD4L inhibits TGF-beta signalling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Down-regulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels.
For research use only.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IHC-P | IHC-F | IF/ICC | Flow Cytometry | ELISA | IP | ChIP |
|---|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Promab and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
NEDD4L identifies NEDD4 like E3 ubiquitin protein ligase in Homo sapiens (Human). This target record connects NCBI Gene 23327, UniProtKB Q96PU5 and related ABMIUM catalogue products.
