TNFa / TNF-alpha, N-His, recombinant protein (E.coli) from ProteoGenix; catalogue PX-P5960; research use only.
Know who made it. See the evidence. Buy through one marketplace.
TNF-alpha (tumor necrosis factor-alpha) is a cytokine protein produced by various cells in the body. It is a type of pro-inflammatory cytokine, meaning it plays an important role in the body’s immune response.
StructureTNF-alpha is a homotrimeric glycoprotein composed of three identical subunits, each around 17 kDa in size. Each subunit is composed of an N-terminal signal peptide, a pro-region, and a mature region.
ActivityTNF-alpha is involved in a variety of cellular processes, including cell differentiation, apoptosis, and the regulation of immune responses. It binds to two distinct receptors, TNFR1 and TNFR2, and activates a variety of intracellular signaling pathways.
ApplicationTNF-alpha is a key mediator of inflammation, and has been implicated in a variety of diseases, including rheumatoid arthritis, psoriasis, and Crohn’s disease. As such, it has become a major target for therapeutic intervention. A number of TNF-alpha inhibitors have been developed for the treatment of these conditions.
ProteoGenix catalogue number PX-P5960. For research use only.
Host: Escherichia coli (E.coli); Expression system: Prokaryotic expression; Purity: >90% as determined by SDS-PAGE; Molecular weight: 19.66 kDa; Tag: N-terminal His Tag; Fragment: Val77-Leu233; Buffer: PBS, pH7.5; Applications: ELISA, WB.
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
