Recombinant Mouse CD115/CSF1R Protein, N-His from ProteoGenix; catalogue ARO-P11020; research use only.
Know who made it. See the evidence. Buy through one marketplace.
Recombinant Mouse CD115/CSF1R Protein is a highly versatile and important protein in the field of immunology and cell biology. It is a type I transmembrane protein that belongs to the class III receptor tyrosine kinase family. This protein is also known as Colony Stimulating Factor 1 Receptor (CSF1R) or Macrophage Colony Stimulating Factor Receptor (M-CSFR). It is primarily expressed on the surface of cells of the myeloid lineage, including macrophages, monocytes, and dendritic cells. In this article, we will explore the structure, activity, and applications of Recombinant Mouse CD115/CSF1R Protein.
The Recombinant Mouse CD115/CSF1R Protein is a 972 amino acid protein with a predicted molecular mass of approximately 108 kDa. It contains a large extracellular domain, a single transmembrane domain, and a cytoplasmic domain. The extracellular domain consists of five immunoglobulin-like domains, while the cytoplasmic domain contains a tyrosine kinase catalytic domain. The binding of its ligand, Colony Stimulating Factor 1 (CSF1), to the extracellular domain induces dimerization and activation of the tyrosine kinase activity of the cytoplasmic domain.
The primary function of Recombinant Mouse CD115/CSF1R Protein is to act as a receptor for the cytokine CSF1. Upon binding of CSF1, the receptor undergoes dimerization and autophosphorylation, leading to the activation of downstream signaling pathways. These signaling pathways play a crucial role in the development, differentiation, and survival of cells of the myeloid lineage. Additionally, Recombinant Mouse CD115/CSF1R Protein also plays a role in regulating the inflammatory response by promoting the recruitment and activation of macrophages and other immune cells to sites of infection or injury.
Recombinant Mouse CD115/CSF1R Protein has a wide range of applications in both research and clinical settings. Some of the major applications include:
Recombinant Mouse CD115/CSF1R Protein is a valuable tool for studying the role of CSF1R signaling in various immune cell functions. It can be used to investigate the effects of CSF1R activation on cell proliferation, differentiation, and survival. Additionally, it can also be used to study the interactions between CSF1R and other receptors or signaling pathways in the immune system.
The overexpression of CSF1R has been linked to various types of cancer, including breast cancer, ovarian cancer, and leukemia. Recombinant Mouse CD115/CSF1R Protein can be used to study the role of CSF1R in cancer development and progression. It can also be used to develop potential therapeutic strategies targeting CSF1R in cancer treatment.
Recombinant Mouse CD115/CSF1R Protein can be used in drug discovery and development as a target for screening potential CSF1R inhibitors. It can also be used to evaluate the efficacy and safety of CSF1R-targeting drugs in preclinical studies.
The expression of CSF1R has been associated with various diseases, including autoimmune disorders and neurodegenerative diseases. Recombinant Mouse CD115/CSF1R Protein can be used as a diagnostic tool to measure the levels of CSF1R in patient samples, providing valuable information for disease diagnosis and monitoring.
Recombinant Mouse CD
ProteoGenix catalogue number ARO-P11020. For research use only.
Host: Escherichia coli (E.coli); Expression system: Prokaryotic expression; Molecular weight: 21.90 kDa; Fragment: Val22-Val198; Buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol..
Available configurations: 50ug, 100ug, 1mg.
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
