Recombinant Human BBS7 Protein, N-His from ProteoGenix; catalogue ARO-P11611; research use only.
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Recombinant Human BBS7 Protein, also known as Bardet-Biedl syndrome 7 protein, is a key component of the BBSome complex. This protein is encoded by the BBS7 gene and plays a crucial role in the development and maintenance of cilia, which are hair-like structures found on the surface of cells. Dysfunction of this protein has been linked to the development of Bardet-Biedl syndrome, a rare genetic disorder characterized by a wide range of symptoms including obesity, vision loss, and kidney abnormalities.
The BBS7 gene, located on chromosome 4, encodes a protein of 723 amino acids. The recombinant form of this protein is produced by cloning the gene into an expression vector and introducing it into a suitable host cell, such as E. coli or yeast. The resulting protein is then purified using various chromatography techniques to obtain a highly pure and active form of Recombinant Human BBS7 Protein.
The crystal structure of Recombinant Human BBS7 Protein has been determined, revealing a three-dimensional structure consisting of seven alpha-helices and four beta-sheets. This structure is highly conserved among different species, indicating the importance of this protein in cellular function.
Recombinant Human BBS7 Protein is a key component of the BBSome complex, which is involved in the transport of proteins and signaling molecules to and from the cilia. This complex is essential for the proper functioning of cilia, which are involved in a wide range of cellular processes including sensory perception, cell signaling, and development.
Studies have shown that Recombinant Human BBS7 Protein interacts with other BBSome components, such as BBS1, BBS2, and BBS9, to form a stable complex that is required for ciliary trafficking. This protein has also been found to interact with other proteins involved in ciliary function, such as Rab8 and Rab11, further highlighting its important role in cilia biology.
Recombinant Human BBS7 Protein has a wide range of applications in both research and therapeutic settings. Its role in cilia biology makes it a valuable tool for studying ciliary function and dysfunction, as well as the development and progression of Bardet-Biedl syndrome.
In research, Recombinant Human BBS7 Protein can be used to study the interactions between different BBSome components and their role in ciliary trafficking. It can also be used to investigate the effects of BBS7 mutations on cilia function and the development of Bardet-Biedl syndrome.
In therapeutic applications, Recombinant Human BBS7 Protein has the potential to be used as a therapeutic target for the treatment of Bardet-Biedl syndrome. Studies have shown that restoring the activity of this protein can improve cilia function and alleviate some of the symptoms associated with this disorder.
In summary, Recombinant Human BBS7 Protein is a crucial component of the BBSome complex, involved in ciliary trafficking and maintenance. Its structure, activity, and potential applications make it a valuable tool for studying cilia biology and the development of Bardet-Biedl syndrome. Further research on this protein may lead to a better understanding of cilia-related disorders and the development of targeted therapies for these conditions.
ProteoGenix catalogue number ARO-P11611. For research use only.
Host: Escherichia coli (E.coli); Expression system: Prokaryotic expression; Molecular weight: 27.32 kDa; Fragment: Gly380-Glu599; Buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol..
Available configurations: 50ug, 100ug, 1mg.
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
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