Metelimumab Biosimilar – Anti-TGFB1 mAb – Research Grade from ProteoGenix; catalogue PX-TA1138; research use only.
Know who made it. See the evidence. Buy through one marketplace.
Metelimumab Biosimilar, also known as anti-TGFB1 mAb, is a research grade antibody that targets the protein transforming growth factor beta 1 (TGFB1). This antibody is being developed as a potential therapeutic option for various diseases and conditions related to TGFB1 dysregulation. In this article, we will explore the structure, activity, and potential applications of Metelimumab Biosimilar.
Metelimumab Biosimilar is a monoclonal antibody, meaning it is produced from a single type of immune cell. It is a humanized antibody, which means it is derived from non-human sources but has been modified to be more similar to human antibodies. This allows for better compatibility and reduced risk of immune reactions in patients.
The antibody is composed of two heavy chains and two light chains, which are connected by disulfide bonds. It has a molecular weight of approximately 150 kDa. Metelimumab Biosimilar specifically binds to the active form of TGFB1, preventing it from interacting with its receptors and exerting its effects.
TGFB1 is a multifunctional cytokine that plays a crucial role in various physiological processes, including cell growth, differentiation, and immune response. However, dysregulation of TGFB1 has been linked to the development and progression of many diseases, including cancer, fibrosis, and autoimmune disorders.
Metelimumab Biosimilar works by specifically binding to TGFB1 and inhibiting its activity. This prevents TGFB1 from promoting inflammation, fibrosis, and other pathological processes. By targeting the active form of TGFB1, Metelimumab Biosimilar has the potential to treat a wide range of diseases and conditions associated with TGFB1 dysregulation.
As mentioned earlier, Metelimumab Biosimilar has the potential to be used as a therapeutic option for various diseases and conditions related to TGFB1 dysregulation. Some of the potential applications of this antibody include:
Cancer TGFB1 has been shown to promote tumor growth and metastasis in various types of cancer. By inhibiting TGFB1 activity, Metelimumab Biosimilar could potentially slow down tumor growth and prevent its spread to other parts of the body. This antibody could also be used in combination with other cancer treatments to enhance their effectiveness.
Fibrosis is a condition characterized by the excessive accumulation of scar tissue in organs. TGFB1 is a major contributor to the development of fibrosis, and its inhibition by Metelimumab Biosimilar could potentially slow down or even reverse the progression of this condition.
In autoimmune disorders, the immune system mistakenly attacks healthy tissues in the body. TGFB1 has been shown to play a role in the development and maintenance of autoimmune responses. By inhibiting TGFB1 activity, Metelimumab Biosimilar could potentially reduce the severity of autoimmune disorders and improve patient outcomes.
Besides the above-mentioned conditions, Metelimumab Biosimilar could also have potential applications in other diseases and conditions, such as pulmonary fibrosis, diabetic nephropathy, and inflammatory bowel disease. Further research and clinical trials are needed to explore the full potential of this antibody.
In conclusion, Metelimumab Biosimilar is a research grade antibody that specifically targets the active form of TGFB1. By inhibiting TGFB1 activity, this antibody has the potential to treat a wide range of diseases and conditions related to TGFB1 dysregulation. With ongoing research and development, Metelimumab Biosimilar could potentially become a valuable therapeutic option for patients in the future.
ProteoGenix catalogue number PX-TA1138. For research use only.
Target: Metelimumab Biosimilar – Anti-TGFB1 mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: Mammalian cells; Purity: >85%; Buffer: PBS buffer PH7.5; Applications: ELISA, WB.
Available configurations: 50ug, 100ug, 1mg.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Target | WB | IHC-P | IHC-Fr | IF/ICC | Flow Cyt | IP | ChIP | ELISA |
|---|---|---|---|---|---|---|---|---|
| Metelimumab Biosimilar – Anti-TGFB1 mAb – Research Grade |
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
