Efmitermant alfa Biosimilar – Anti-GDF-8 fusion protein – Research Grade from ProteoGenix; catalogue PX-TA2039; research use only.
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Efmitermant alfa Biosimilar is a novel fusion protein that has gained significant attention in the field of biopharmaceuticals. It is a biosimilar of Efmitermant alfa, a recombinant protein used for the treatment of anemia associated with chronic kidney disease. This biosimilar is designed to target growth and differentiation factor 8 (GDF-8), a protein involved in regulating muscle growth and development. In this article, we will explore the structure, activity, and potential applications of Efmitermant alfa Biosimilar as a therapeutic antibody.
Efmitermant alfa Biosimilar is a fusion protein composed of two components: Efmitermant alfa and an anti-GDF-8 antibody. The Efmitermant alfa component is a glycosylated protein with a molecular weight of approximately 30 kDa. It is produced in Chinese hamster ovary (CHO) cells using recombinant DNA technology. The anti-GDF-8 antibody component is a monoclonal antibody that specifically binds to GDF-8 with high affinity. It is a human IgG1 antibody with a molecular weight of approximately 150 kDa.
The two components of Efmitermant alfa Biosimilar are linked together by a flexible linker peptide, resulting in a final molecular weight of approximately 180 kDa. This fusion protein has a similar structure to the native GDF-8 protein, allowing it to bind to GDF-8 with high specificity and potency.
Efmitermant alfa Biosimilar exerts its therapeutic effects by inhibiting the activity of GDF-8. GDF-8 is a member of the transforming growth factor-beta (TGF-β) superfamily and plays a crucial role in regulating muscle growth and development. In healthy individuals, GDF-8 helps maintain muscle homeostasis by inhibiting muscle growth and promoting muscle atrophy. However, in certain disease conditions, such as cancer cachexia and muscular dystrophy, GDF-8 is overexpressed, leading to excessive muscle wasting.
By binding to GDF-8, Efmitermant alfa Biosimilar blocks its interaction with its receptor, preventing the downstream signaling cascade that promotes muscle atrophy. This results in increased muscle mass and improved muscle function, making it a promising therapeutic target for various muscle-related disorders.
Efmitermant alfa Biosimilar has shown promising results in preclinical studies for the treatment of various muscle-related disorders. In a mouse model of cancer cachexia, treatment with Efmitermant alfa Biosimilar resulted in increased muscle mass and improved muscle function. In a mouse model of muscular dystrophy, it improved muscle strength and reduced muscle degeneration. These results suggest that Efmitermant alfa Biosimilar could be a potential therapeutic option for these conditions.
Furthermore, GDF-8 has also been implicated in other diseases, such as osteoporosis and type 2 diabetes. Inhibition of GDF-8 activity by Efmitermant alfa Biosimilar could potentially have beneficial effects in these diseases as well. Clinical trials are currently underway to evaluate the safety and efficacy of Efmitermant alfa Biosimilar in these conditions.
Efmitermant alfa Biosimilar is a novel fusion protein designed to target GDF-8, a protein involved in regulating muscle growth and development. Its unique structure and mechanism of action make it a promising therapeutic option for various muscle-related disorders. With ongoing research and clinical trials, Efmitermant alfa Biosimilar has the potential to improve the lives of patients suffering from these conditions.
ProteoGenix catalogue number PX-TA2039. For research use only.
Target: Efmitermant alfa Biosimilar – Anti-GDF-8 fusion protein – Research Grade; Expression system: XtenCHO; Purity: >90% by SDS-PAGE.; Buffer: 0.01M PBS, pH 7.4.; Applications: ELISA, WB.
Available configurations: 50ug, 100ug, 1mg.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Target | WB | IHC-P | IHC-Fr | IF/ICC | Flow Cyt | IP | ChIP | ELISA |
|---|---|---|---|---|---|---|---|---|
| Efmitermant alfa Biosimilar – Anti-GDF-8 fusion protein – Research Grade |
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
