CD274 / PD-L1 / B7-H1, C-His, recombinant protein from ProteoGenix; catalogue PX-P5607; research use only.
Know who made it. See the evidence. Buy through one marketplace.
CD274, also known as PD-L1 or B7-H1, is a type I transmembrane glycoprotein that is expressed on the surface of various cell types, including T cells, B cells, macrophages, dendritic cells, and some tumor cells. The extracellular domain of CD274 is composed of three immunoglobulin-like domains, while the intracellular domain contains a cytoplasmic tail that is important for the regulation of its activity.
CD274 / PD-L1 / B7-H1 ActivityCD274 acts as an inhibitory receptor that binds to its ligand, programmed death ligand 1 (PD-L1). This interaction between CD274 and PD-L1 results in the inhibition of T cell activation and proliferation, as well as the induction of anergy and apoptosis in T cells. In addition, CD274 can also bind to other ligands, including B7 family members, which can lead to the activation of T cells.
CD274 / PD-L1 / B7-H1 ApplicationCD274 has been studied extensively in the context of cancer immunotherapy, as it is often overexpressed on tumor cells.
ProteoGenix catalogue number PX-P5607. For research use only.
Host: Mammalian cells; Expression system: Eukaryotic expression; Purity: >90% as determined by SDS-PAGE; Molecular weight: 33.28 kDa; Tag: C-terminal His Tag; Fragment: Met1-Arg238; Buffer: PBS, pH7.5; Applications: ELISA, WB.
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
