Manufactured by:ProteoGenix
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Brivekimig Biosimilar – Anti-CD252;TNFA;ALB mAb – Research Grade

Brivekimig Biosimilar – Anti-CD252;TNFA;ALB mAb – Research Grade from ProteoGenix; catalogue PX-TA2180; research use only.

SKU:
ABM133867-1
Manufacturer SKU
PX-TA2180
Product type
Primary Antibodies
TargetBrivekimig Biosimilar – Anti-CD252;TNFA;ALB mAb – Research Grade
Expression systemXtenCHO
Purity>95% by SDS-PAGE

Manufacturer provenance

Manufactured by:
ProteoGenix
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

Introduction

Brivekimig Biosimilar – Anti-CD252;TNFA;ALB mAb – Research Grade is a therapeutic antibody that has been designed to target and inhibit the activity of CD252, TNFA, and ALB. This biosimilar is a highly specific and potent treatment option for a variety of diseases and conditions, and has shown promising results in clinical trials.

Structure

Brivekimig Biosimilar is a monoclonal antibody (mAb) that is produced through recombinant DNA technology. It is a humanized antibody, meaning that it is derived from non-human sources but has been modified to be more similar to human antibodies. This modification reduces the likelihood of adverse reactions and improves the efficacy of the antibody.

The antibody has a complex structure, consisting of two heavy chains and two light chains, each with a specific amino acid sequence. The heavy chains are responsible for binding to the target molecules, while the light chains aid in the stability and function of the antibody.

The binding region of the antibody, also known as the variable region, is highly specific for CD252, TNFA, and ALB. This allows the antibody to selectively target and bind to these molecules, inhibiting their activity and preventing them from causing harm.

Activity

The primary activity of Brivekimig Biosimilar is to inhibit the activity of CD252, TNFA, and ALB. These molecules are known to play a role in various inflammatory and autoimmune diseases, as well as cancer. By binding to these molecules, the antibody blocks their function and reduces the inflammatory response, leading to improved disease outcomes.

In addition to its anti-inflammatory activity, Brivekimig Biosimilar also has immunomodulatory effects. It can regulate the activity of immune cells, such as T cells and B cells, and promote a more balanced immune response. This is particularly beneficial in autoimmune diseases where the immune system is overactive and attacking healthy tissues.

Furthermore, the antibody has been shown to have a direct cytotoxic effect on cancer cells. By binding to TNFA, which is often overexpressed in cancer cells, Brivekimig Biosimilar can induce cell death and inhibit tumor growth.

Application

Brivekimig Biosimilar has a wide range of applications in the treatment of various diseases and conditions. Its anti-inflammatory and immunomodulatory properties make it a promising option for the treatment of autoimmune diseases, such as rheumatoid arthritis, psoriasis, and Crohn’s disease.

The antibody also has potential in the treatment of inflammatory conditions, such as asthma and allergies, where CD252 and TNFA play a role in the inflammatory response. It has shown promising results in clinical trials for these indications.

In addition, Brivekimig Biosimilar has shown potential as a cancer treatment. Its ability to directly target and kill cancer cells, as well as its immunomodulatory effects, make it a promising option for various types of cancer, including solid tumors and hematological malignancies.

Conclusion

In summary, Brivekimig Biosimilar – Anti-CD252;TNFA;ALB mAb – Research Grade is a highly specific and potent therapeutic antibody with a complex structure and multiple activities. Its ability to target and inhibit the activity of CD252, TNFA, and ALB makes it a promising treatment option for a wide range of diseases and conditions, including autoimmune diseases, inflammatory conditions, and cancer. Further research and clinical trials are needed to fully explore the potential of this biosimilar in improving patient outcomes.

ProteoGenix catalogue number PX-TA2180. For research use only.

Target: Brivekimig Biosimilar – Anti-CD252;TNFA;ALB mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: XtenCHO; Purity: >95% by SDS-PAGE; Buffer: 0.01M PBS, pH 7.4.

Available configurations: 50ug, 100ug, 1mg.

Download the manufacturer datasheet

Key facts & specifications
Also known as
anti-CD252, OX40L, TXGP1, OX40 ligand, Glycoprotein Gp34, TAX transcriptionally-activated glycoprotein 1, TNFSF4, Tumor necrosis factor ligand superfamily member 4, TNF, Tumor necrosis factor ligand superfamily member 2, N-terminal fragment, ICD2, NTF, TNF-a, TNF-alpha, Tumor necrosis factor, TNFSF2, TNFA, Cachectin, ICD1, ALB, Albumin
Clonality
Monoclonal
Isotype
Ig IG single chain of 5 VH (VH-VH-VH'-VH''-VH') monomer
Source organism
Human
Sequence
MERVQPLEENVGNAARPRFERNKLLLVASVIQGLGLLLCFTYICLHFSALQVSHRYPRIQSIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEFCVL
Technical note
For research use only. Not suitable for human use.
Identifiers & database references
Manufacturer SKU
PX-TA2180
UniProt accession
P23510 & P01375 & P02768
Storage, stability & shipping
Storage conditions
4°C for short term; -20°C for long term
Shipped at
Blue ice (+4°C)
Compliance & documents
ISO certifications
ISO 9001:2023, ISO 14001: 2023
Datasheet
Open datasheet
Frequently asked questions
Who manufactured this product?

This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

ProteoGenix
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