Anti-PHOX2B Polyclonal Antibody from ProteoGenix; catalogue ARO-A22060; research use only.
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Anti-PHOX2B Polyclonal Antibody: A Powerful Tool for Studying Neural Development and Disorders
The Anti-PHOX2B Polyclonal Antibody is a highly specific and sensitive tool for studying the role of PHOX2B in neural development and disorders. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the human PHOX2B protein sequence. It has been extensively validated for use in various applications, making it a reliable choice for researchers in the field of biotechnology.
PHOX2B is a transcription factor that plays a critical role in the development of the autonomic nervous system. It is involved in the differentiation and maturation of neurons and controls the expression of genes involved in autonomic functions such as breathing, heart rate, and digestion. Mutations in the PHOX2B gene have been linked to various neural disorders, including congenital central hypoventilation syndrome and neuroblastoma.
The Anti-PHOX2B Polyclonal Antibody is primarily used in immunohistochemistry (IHC) and Western blotting (WB) techniques to detect the expression of PHOX2B in tissue samples. It has also been successfully used in chromatin immunoprecipitation (ChIP) assays to study the binding of PHOX2B to specific DNA sequences. Moreover, this antibody has been used in fluorescence-activated cell sorting (FACS) analysis to isolate PHOX2B-expressing cells from complex tissue samples.
The Anti-PHOX2B Polyclonal Antibody has been used in various experimental studies to investigate the role of PHOX2B in neural development and disorders. For example, researchers have used this antibody to study the expression of PHOX2B in neuroblastoma cell lines and primary tumors, providing valuable insights into the pathogenesis of this aggressive childhood cancer. Additionally, this antibody has been used to identify PHOX2B-expressing neurons in the brainstem, helping to unravel the complex neural circuits involved in autonomic functions.
Conclusion:
In summary, the Anti-PHOX2B Polyclonal Antibody is a highly specific and sensitive tool for studying the role of PHOX2B in neural development and disorders. Its reliable performance in various applications and extensive validation make it a valuable asset for researchers in the biotechnology field. Whether you are studying neural development, neurodegenerative diseases, or cancer, this antibody will provide you with accurate and reproducible results, helping you advance your research and contribute to the understanding of complex biological processes.
ProteoGenix catalogue number ARO-A22060. For research use only.
Target: Paired mesoderm homeobox protein 2B; Neuroblastoma Phox; NBPhox; PHOX2B homeodomain protein; Paired-like homeobox 2B; PHOX2B; PMX2B; Clonality: Polyclonal Antibody; Applications: IHC, ELISA.
Available configurations: 50ug, 100ug, 1mg.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Target | WB | IHC-P | IHC-Fr | IF/ICC | Flow Cyt | IP | ChIP | ELISA | IHC |
|---|---|---|---|---|---|---|---|---|---|
| Paired mesoderm homeobox protein 2B; Neuroblastoma Phox; NBPhox; PHOX2B homeodomain protein; Paired-like homeobox 2B; PHOX2B; PMX2B |
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
