Anti-LGR4 Biosimilar – Anti-LGR4 mAb – Research Grade from ProteoGenix; catalogue PX-TA1626; research use only.
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Anti-LGR4 Biosimilar, also known as Anti-LGR4 monoclonal antibody (mAb), is a novel therapeutic agent that targets the LGR4 protein. LGR4 is a member of the leucine-rich repeat-containing G protein-coupled receptor (LGR) family and has been identified as a potential therapeutic target for various diseases. In this article, we will discuss the structure, activity, and potential applications of Anti-LGR4 Biosimilar as a research-grade antibody.
Anti-LGR4 Biosimilar is a monoclonal antibody that is produced by recombinant DNA technology. It is a glycoprotein with a molecular weight of approximately 150 kDa. The antibody consists of two identical heavy chains and two identical light chains, which are connected by disulfide bonds. The heavy chains are composed of four constant domains (CH1, CH2, CH3, and CH4) and one variable domain (VH), while the light chains contain one constant domain (CL) and one variable domain (VL). The variable domains of both the heavy and light chains are responsible for binding to the LGR4 protein.
The main activity of Anti-LGR4 Biosimilar is to specifically bind to the LGR4 protein and inhibit its function. LGR4 is a receptor that is involved in various signaling pathways, including the Wnt/β-catenin pathway, which plays a crucial role in cell proliferation, differentiation, and migration. Overexpression of LGR4 has been observed in many types of cancer, and it has been linked to tumor growth and metastasis. Therefore, by targeting LGR4, Anti-LGR4 Biosimilar can potentially inhibit the growth and spread of cancer cells.
In addition to its anti-tumor activity, Anti-LGR4 Biosimilar has also been shown to have anti-inflammatory effects. LGR4 has been found to be involved in the regulation of immune responses, and its overexpression has been associated with chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. By blocking LGR4, Anti-LGR4 Biosimilar can potentially reduce inflammation and alleviate symptoms of these diseases.
As a research-grade antibody, Anti-LGR4 Biosimilar has various potential applications in the field of biomedical research. Some of the key applications include:
1. Target validation: LGR4 has been identified as a potential therapeutic target for various diseases, but its exact role in different pathologies is still being investigated. Anti-LGR4 Biosimilar can be used to validate the role of LGR4 in different disease models and provide insights into its mechanism of action.
2. Drug development: By targeting LGR4, Anti-LGR4 Biosimilar can potentially be used as a therapeutic agent for the treatment of cancer and inflammatory diseases. Its ability to specifically bind to LGR4 and inhibit its function makes it a promising candidate for drug development.
3. Biomarker discovery: LGR4 has been found to be overexpressed in certain types of cancer, making it a potential biomarker for early detection and prognosis. Anti-LGR4 Biosimilar can be used to study the expression of LGR4 in different cancer types and its correlation with disease progression.
4. Cell signaling studies: As LGR4 is involved in various signaling pathways, Anti-LGR4 Biosimilar can be used to study the effects of LGR4 inhibition on cell signaling. This can provide insights into the role of LGR4 in different cellular processes and its potential as a therapeutic target.
In summary, Anti-LGR4 Biosimilar is a research-grade antibody that specifically targets the LGR4 protein. Its structure, activity, and potential applications make it a valuable tool for biomedical research. By inhibiting LGR4, Anti-LGR4 Biosimilar has the potential to be developed as a therapeutic agent for the treatment of cancer and inflammatory diseases. Further studies and clinical trials are needed to fully explore the therapeutic potential of Anti-LGR4 Biosimilar.
ProteoGenix catalogue number PX-TA1626. For research use only.
Target: LGR4 Biosimilar – Anti-LGR4 mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: Mammalian cells; Purity: >85%; Buffer: PBS buffer pH7.5; Applications: ELISA, WB.
Available configurations: 50ug, 100ug, 1mg.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Target | WB | IHC-P | IHC-Fr | IF/ICC | Flow Cyt | IP | ChIP | ELISA |
|---|---|---|---|---|---|---|---|---|
| LGR4 Biosimilar – Anti-LGR4 mAb – Research Grade |
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
