Kit ELISA fourni par Boster Bio
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Les inhibiteurs tissulaires de métalloprotéinases (TIMPs) sont des inhibiteurs naturels des métalloprotéinases matricielles, un groupe d'endopeptidases liant le zinc impliquées dans la dégradation de la matrice extracellulaire. Le gène TIMP3 est exprimé dans de nombreux tissus, avec l'expression la plus élevée dans le placenta. TIMP3 code un puissant inhibiteur de l'angiogenèse et est muté dans la dystrophie de Sorsby, une maladie dégénérative maculaire avec néovascularisation choroïdienne sous-maculaire. Le gène TIMP3 est cartographié en 22q12.1-q13.2. Les mutations du TIMP3 sont la cause de la dystrophie du fond d'œil de Sorsby (SFD), un trouble autosomique dominant.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Compatibilité de l'échantillon | Gamme de test | Sensibilité | Spécificité |
|---|---|---|---|---|
| surnageants de culture cellulaire | ||||
| sérum | ||||
| plasma (héparine | ||||
| EDTA) et salive. |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
TIMP3 identifies TIMP metallopeptidase inhibitor 3 in Homo sapiens (Human). This target record connects NCBI Gene 7078, UniProtKB P35625 and related ABMIUM catalogue products.
