Kit ELISA fourni par Boster Bio
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Le facteur dérivé des cellules stromales 1 (SDF-1), également connu sous le nom de chimiokine 12 à motif C-X-C (CXCL12), est une protéine chimiokine qui, chez l'homme, est codée par le gène CXCL12 sur le chromosome 10. Ce gène antimicrobien code une alpha-chimiokine dérivée des cellules stromales, membre de la famille des intercrines. La protéine codée fonctionne comme le ligand du récepteur couplé aux protéines G, le récepteur 4 des chimiokines (motif C-X-C), et joue un rôle dans de nombreuses fonctions cellulaires diverses, y compris l'embryogenèse, la surveillance immunitaire, la réponse inflammatoire, l'homéostasie tissulaire, et la croissance et la métastase tumorales. Les mutations de ce gène sont associées à la résistance aux infections par le virus de l'immunodéficience humaine de type 1. Plusieurs variants de transcription codant différentes isoformes ont été trouvés pour ce gène.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Compatibilité de l'échantillon | Gamme de test | Sensibilité | Spécificité |
|---|---|---|---|---|
| surnageants de culture cellulaire | ||||
| sérum et plasma (héparine | ||||
| EDTA) |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
C-X-C motif chemokine ligand 12 (CXCL12), widely known as stromal cell-derived factor 1 (SDF-1), is a chemokine central to chemotaxis and cell trafficking. This hub connects verified names and identifiers with ABMIUM catalogue products.
Biological function: C-X-C motif chemokine ligand 12 (CXCL12/SDF-1) is a chemoattractant for T lymphocytes and monocytes. Reviewed UniProt evidence shows signalling through CXCR4 to induce calcium responses and chemotaxis, with additional binding to the atypical chemokine receptor ACKR3.
