Kit ELISA fourni par Boster Bio
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L'arylsulfatase A (ou cérébroside-sulfatase) est une enzyme qui décompose les sulfatides, notamment le cérébroside 3-sulfate, en cérébroside et sulfate. Chez l'homme, l'arylsulfatase A est codée par le gène ARSA. Il est localisé en 22q13.33. La protéine codée par ce gène hydrolyse le sulfate de cérébroside en cérébroside et sulfate. Des défauts dans ce gène entraînent la leucodystrophie métachromatique (MLD), une maladie démyélinisante progressive qui entraîne une variété de symptômes neurologiques et finalement la mort. Des variants de transcrits épissés alternativement ont été décrits pour ce gène.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Compatibilité de l'échantillon | Gamme de test | Sensibilité | Spécificité |
|---|---|---|---|---|
| surnageants de cultures cellulaires | ||||
| sérum et plasma (héparine | ||||
| EDTA | ||||
| citrate). |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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ARSA encodes arylsulfatase A, also known as ASA, a lysosomal sulfatase that degrades cerebroside-3-sulfate (sulfatide). The enzyme is a key component of lysosomal glycosphingolipid catabolism. Abmium catalogue products linked below support research into ARSA expression, lysosomal function and sulfatide metabolism.
Biological function: Arylsulfatase A is a lysosomal hydrolase that catalyses cleavage of sulfate from cerebroside-3-sulfate, producing cerebroside and sulfate; the reaction requires saposin B. This activity supports turnover of sulfatides and normal lysosomal lipid metabolism. Reduced ARSA activity causes sulfatide accumulation, making the enzyme a central mechanistic target in metachromatic leukodystrophy research.
