Anticorps polyclonal anti-Btk de lapin, fourni par ELK Biotechnology
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L'anticorps pAb de lapin anti-Btk est un anticorps d'ELK Biotechnology destiné aux flux de travail de recherche impliquant Btk.
La protéine codée par ce gène joue un rôle crucial dans le développement des lymphocytes B. Les mutations de ce gène entraînent l'agammaglobulinémie liée à l'X de type 1, une immunodéficience caractérisée par l'incapacité à produire des lymphocytes B matures, et associée à un échec du réarrangement de la chaîne lourde des Ig. L'épissage alternatif aboutit à de multiples variantes de transcrits codant différentes isoformes. [fourni par RefSeq, déc. 2013],
| Spécificité | L'anticorps polyclonal Btk détecte les niveaux endogènes de protéine Btk uniquement en l'absence de phosphorylation en Y550. |
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Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Humain | |||||||
| Souris | |||||||
| Rat |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
BTK (Bruton tyrosine kinase), also known as tyrosine-protein kinase BTK, is a TEC-family non-receptor tyrosine kinase central to B-cell receptor signalling and B-lymphocyte development.
Biological function: Following B-cell receptor engagement, BTK is activated at the plasma membrane and phosphorylates PLCG2, promoting calcium mobilization and downstream protein kinase C signalling. This kinase activity is central to B-cell activation, differentiation and immune signalling.
