Anticorps polyclonal anti-ADM de chez ELK Biotechnology
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ADM rabbit pAb est un anticorps d'ELK Biotechnology pour les flux de travail de recherche impliquant l'ADM.
La protéine encodée par ce gène est une préprohormone qui est clivée pour former deux peptides biologiquement actifs, l'adrénomédulline et le peptide N-terminal 20 de la proadrénomédulline. L'adrénomédulline est un peptide de 52 acides aminés ayant plusieurs fonctions, notamment la vasodilatation, la régulation de la sécrétion hormonale, la promotion de l'angiogenèse et l'activité antimicrobienne. L'activité antimicrobienne est antibactérienne, car le peptide s'est avéré capable de tuer E. coli et S. aureus à faible concentration. [fourni par RefSeq, août 2014]
| Spécificité | L'anticorps polyclonal ADM détecte les niveaux endogènes de protéine ADM. |
|---|---|
| Légendes des preuves de validation | Analyse par Western Blot de cellules de rein de souris, de poumon de souris, de cœur de souris utilisant l'anticorps polyclonal ADM. L'anticorps secondaire (réf. catalogue : RS0002) a été dilué à 1:20000 | Analyse immunohistochimique de foie humain inclus en paraffine, l'anticorps a été dilué à 1:100 | Analyse immunohistochimique de foie humain inclus en paraffine, l'anticorps a été dilué à 1:100 | Analyse immunohistochimique de rein de rat inclus en paraffine, l'anticorps a été dilué à 1:100 |
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Humain | |||||||
| Rat |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Adrenomedullin (ADM; AM) is produced from the pro-adrenomedullin precursor, which also gives rise to proadrenomedullin N-terminal peptide (PAMP). Human ADM is represented by NCBI Gene 133 and reviewed UniProtKB P35318, with related ABMIUM catalogue reagents for research use.
Biological function: The ADM gene encodes pro-adrenomedullin, a precursor processed into biologically active peptides including adrenomedullin and PAMP. Curated NCBI and UniProt records describe adrenomedullin as a vasoactive peptide with potent vasodilatory and hypotensive activity and roles in fluid and electrolyte homeostasis; reviewed UniProt identifies signalling through CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes.
