BACE (Phospho Ser498) lapin pAb de ELK Biotechnology
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L'anticorps monoclonal de lapin BACE (Phospho Ser498) est un anticorps d'ELK Biotechnology pour les flux de travail de recherche impliquant BACE.
bêta-sécrétase 1 (BACE1) Homo sapiens Ce gène code pour un membre de la famille des aspartyl protéases A1 des peptidases. L'épissage alternatif produit plusieurs variants de transcrits, dont au moins un code pour une préproprotéine qui est traitée protéolytiquement pour générer la protéase mature. Cette protéase transmembranaire catalyse la première étape de la formation du peptide bêta amyloïde à partir de la protéine précurseur amyloïde. Les peptides bêta amyloïdes sont le constituant principal des plaques amyloïdes bêta, qui s'accumulent dans le cerveau des patients humains atteints de la maladie d'Alzheimer. [fourni par RefSeq, Nov 2015]
| Spécificité | Cet anticorps détecte les niveaux endogènes de BACE (Phospho Ser498) humain, de souris et de rat. |
|---|---|
| Légendes des preuves de validation | Analyse par Western Blot de lysats de cellules Hela traitées ou non traitées par LPS, à l'aide d'un anticorps primaire à une dilution de 1:1000. L'anticorps secondaire (réf. : RS23920) a été dilué à 1:10000. |
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Humain | |||||||
| Souris | |||||||
| Rat |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Beta-secretase 1 (BACE1), also known as BACE, is a membrane aspartyl protease best known for initiating beta-site processing of amyloid precursor protein (APP). This target page groups ABMIUM catalogue reagents for studying APP proteolysis, amyloid-beta pathway biology and BACE1-dependent neuronal protein processing.
Biological function: BACE1 is a type I transmembrane aspartyl protease. It cleaves APP at the beta-secretase site, generating the C99 fragment that can be further processed by gamma-secretase to produce amyloid-beta peptides. BACE1 activity is favoured in acidic intracellular compartments such as endosomes, and the enzyme also processes additional neuronal membrane proteins.
