ATG12 lapin pAb de ELK Biotechnology
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L'anticorps polyclonal de lapin anti-ATG12 est un anticorps ELK Biotechnology destiné aux flux de travail de recherche impliquant ATG12.
L'autophagie est un processus de dégradation des protéines en vrac dans lequel les composants cytoplasmiques, y compris les organites, sont enfermés dans des structures à double membrane appelées autophagosomes et délivrés aux lysosomes ou aux vacuoles pour dégradation. ATG12 est l'homologue humain d'une protéine de levure impliquée dans l'autophagie (Mizushima et al., 1998 [PubMed 9852036]). [fourni par OMIM, mars 2008],
| Spécificité | Cet anticorps détecte les niveaux endogènes d'ATG12 chez l'homme/la souris/le rat. |
|---|---|
| Légendes des preuves de validation | Analyse par Western blot de lysats de cellules HpeG2, l'anticorps primaire a été dilué à 1:1000, 4° pendant la nuit. |
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Humain | |||||||
| Souris | |||||||
| Rat |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
ATG12 (autophagy related 12) encodes ubiquitin-like protein ATG12, a core autophagy factor that forms the ATG12-ATG5 conjugate required for autophagosome membrane formation.
Biological function: Ubiquitin-like protein ATG12 is covalently conjugated to ATG5 through an ATG7- and ATG10-dependent system. The ATG12-ATG5 complex, together with ATG16L1, acts as an E3-like factor that promotes ATG8-family lipidation and association with developing autophagic membranes.
