ARC rabbit pAb de ELK Biotechnology
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L'anticorps pAb anti-ARC est un anticorps d'ELK Biotechnology destiné aux flux de travail de recherche impliquant ARC.
fonction:Nécessaire à la consolidation de la plasticité synaptique ainsi qu'à la formation de la mémoire à long terme. Régule l'endocytose des récepteurs AMPA en réponse à l'activité synaptique. Nécessaire à la mise à l'échelle synaptique homéostatique des récepteurs AMPA.,similarité:Appartient à la famille ARC/ARG3.1.,localisation subcellulaire:Associé au cortex cellulaire du soma neuronal et des dendrites. Enrichi dans la densité postsynaptique des épines dendritiques. Associé à la queue du spermatozoïde.,sous-unité:Interagit avec SH3GL1/endophiline-2, SH3GL3/endophiline-3 et DNM2/DYN2.,
| Spécificité | L'anticorps polyclonal anti-ARC détecte les niveaux endogènes de la protéine. |
|---|---|
| Légendes des preuves de validation | Analyse par Western blot des lysats de cellules KB, l'anticorps primaire a été dilué à 1:1000, 4° pendant la nuit |
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Humain | |||||||
| Rat | |||||||
| Souris |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Activity regulated cytoskeleton associated protein (ARC; Arc/Arg3.1) is an activity-induced neuronal protein and master regulator of synaptic plasticity. This catalogue-backed ABMIUM record links human ARC (NCBI Gene 23237; UniProt Q7LC44) to research reagents.
Biological function: ARC is rapidly induced by neuronal activity and supports protein-synthesis-dependent forms of long-term potentiation and depression, receptor trafficking and long-term memory. ARC can self-assemble into virus-like capsids that package RNA and participate in intercellular RNA transfer.
