ATG7 Lapin pAb d'ELK Biotechnology
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L'anticorps polyclonal de lapin ATG7 est un anticorps d'ELK Biotechnology pour les protocoles de recherche impliquant ATG7.
La machinerie moléculaire de l'autophagie a été largement découverte chez la levure et est désignée sous le nom de gènes liés à l'autophagie (Atg). La formation de l'autophagosome implique un système de conjugaison de type ubiquitine dans lequel Atg12 est lié de manière covalente à Atg5 et ciblé vers les vésicules autophagiques. Cette réaction de conjugaison est médiatisée par l'enzyme Atg7 de type ubiquitine E1 et l'enzyme Atg10 de type E2.
| Légendes des preuves de validation | Analyse immunohistochimique de tissu hépato-carcinomateux humain inclus en paraffine à l'aide de l'anticorps polyclonal de lapin ATG7 (EA351) dilué à 1:200 | Analyse immunohistochimique de tissu de carcinome mammaire humain inclus en paraffine à l'aide de l'anticorps polyclonal de lapin ATG7 (EA351) dilué à 1:200. |
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Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Humain | |||||||
| Souris | |||||||
| Rat |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
ATG7 (autophagy related 7) encodes ubiquitin-like modifier-activating enzyme ATG7, an E1-like enzyme that drives the ATG12-ATG5 and ATG8/LC3 conjugation systems required for autophagosome formation. ABMIUM catalogue products linked below target ATG7; suitability remains product- and application-specific.
Biological function: ATG7 acts as the E1-like activating enzyme for two core autophagy conjugation pathways. It activates ATG12 for conjugation to ATG5 and activates ATG8-family proteins for phosphatidylethanolamine conjugation, supporting LC3 lipidation and autophagosomal membrane formation. Reviewed UniProt also supports a role in mitophagy and mitochondrial quality control.
