ATG5 anticorps polyclonal de lapin d'ELK Biotechnology
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L'anticorps polyclonal de lapin ATG5 est un anticorps d'ELK Biotechnology destiné aux flux de travail de recherche impliquant l'ATG5.
L'autophagie est généralement activée par des conditions de privation de nutriments, mais a également été associée à un certain nombre de processus physiologiques, y compris le développement, la différenciation, la neurodégénérescence, l'infection et le cancer. La formation de l'autophagosome implique un système de conjugaison de type ubiquitine dans lequel l'Atg12 est lié de manière covalente à l'Atg5 et ciblé vers les vésicules autophagosomes. Cette réaction de conjugaison est médiée par l'enzyme Atg7 de type ubiquitine E1 et l'enzyme Atg10 de type E2.
| Légendes des preuves de validation | Analyse immunohistochimique de tissu d'hépatocarcinome humain inclus en paraffine utilisant l'anticorps polyclonal de lapin ATG5 (EA350) dilué à 1:200 | Analyse immunohistochimique de tissu de carcinome ovarien humain inclus en paraffine utilisant l'anticorps polyclonal de lapin ATG5 (EA350) dilué à 1:200. |
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Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Humain | |||||||
| Souris | |||||||
| Rat |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
ATG5 (autophagy related 5), also known as autophagy protein 5, is a core autophagy factor that forms a covalent conjugate with ATG12 and supports ATG8-family lipidation and autophagosome assembly.
Biological function: ATG5 is covalently conjugated to ATG12 through an autophagy-specific ubiquitin-like conjugation pathway. The ATG12-ATG5 complex, together with ATG16L1, provides ATG8-family ligase activity that promotes LC3/GABARAP lipidation on forming autophagosomal membranes and is required for efficient autophagosome assembly.
