MEK1 Lapin pAb de ELK Biotechnology
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Le pAb de lapin MEK1 est un anticorps d'ELK Biotechnology pour les flux de travail de recherche impliquant le MEK1.
MEK1 et MEK2, également appelées kinases MAPK ou Erk, sont des protéines kinases à double spécificité qui fonctionnent dans une cascade de protéines kinases activées par un mitogène, contrôlant la croissance et la différenciation cellulaires. Catalysent la phosphorylation concomitante d'une thréonine et d'un résidu de tyrosine dans une séquence Thr-Glu-Tyr située dans les MAP kinases. Activent les MAP kinases ERK1 et ERK2.
| Légendes des preuves de validation | Analyse par Western blot de 1) Hela, 2) 3T3, 3) PC12 avec le pAb de lapin MEK1 EA219 dilué à 1:2 000. | Analyse immunohistochimique de carcinome du côlon humain inclus en paraffine utilisant le pAb de lapin MEK1 (EA219) dilué à 1:200. | Analyse par Western blot d'extraits de MG63 (Piste 1), MCF-7 (Piste 2), 3T3 (Piste 3), Rein de rat (Piste 4), utilisant le MEK1 dilué à 1:50 000. |
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Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Humain | |||||||
| Rat | |||||||
| Souris |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
MAP2K1 identifies mitogen-activated protein kinase kinase 1 in Homo sapiens (Human). This target record connects NCBI Gene 5604, UniProtKB Q02750 and related ABMIUM catalogue products.
Biological function: Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1; MEK1/MKK1) is a dual-specificity kinase in the RAS-RAF-MEK-ERK pathway. It phosphorylates and activates ERK1/ERK2, coupling upstream growth-factor signals to cellular proliferation, differentiation and survival programs.
