Anticorps primaire fourni par Boster Bio
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L'inhibiteur 1 de la métallopeptidase TIMP, également connu sous le nom de TIMP1, un inhibiteur tissulaire des métalloprotéinases, est une glycoprotéine exprimée par plusieurs tissus d'organismes. Cette protéine est un membre de la famille TIMP. La glycoprotéine est un inhibiteur naturel des métalloprotéinases matricielles (MMP), un groupe de peptidases impliquées dans la dégradation de la matrice extracellulaire. En plus de son rôle inhibiteur contre la plupart des MMP connues, la protéine codée est capable de promouvoir la prolifération cellulaire dans une large gamme de types cellulaires, et peut également avoir une fonction anti-apoptotique. La transcription de ce gène est fortement inductible en réponse à de nombreuses cytokines et hormones. Le TIMP a été trouvé à environ 22 cM proximal de l'OTC (300461).
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Humain | ||||||||
| Souris | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
TIMP1 identifies TIMP metallopeptidase inhibitor 1 in Homo sapiens (Human). This target record connects NCBI Gene 7076, UniProtKB P01033 and related ABMIUM catalogue products.
Biological function: TIMP1 is a natural inhibitor of matrix metalloproteinases that binds active MMPs and limits extracellular-matrix proteolysis.
