Anticorps primaire fourni par Boster Bio
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La survivine, également appelée inhibiteur d'apoptose baculoviral repeat-containing 5 ou BIRC5, est une protéine qui, chez l'homme, est codée par le gène BIRC5. La survivine est un membre de la famille des inhibiteurs d'apoptose (IAP). Le gène de la survivine contient 4 exons. Ce gène est localisé sur le chromosome 17q25 par électrophorèse en champ pulsé et FISH monocouleur et bicolore. La protéine de la survivine fonctionne comme un inhibiteur de l'activation de la caspase, entraînant ainsi une régulation négative de l'apoptose ou de la mort cellulaire programmée. La protéine de la survivine est fortement exprimée dans la plupart des tumeurs humaines et des tissus fœtaux, mais est complètement absente dans les cellules différenciées terminalement.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Mouse |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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BIRC5 (baculoviral IAP repeat containing 5), widely known as survivin, is an inhibitor-of-apoptosis-family protein studied for its roles in mitotic progression, chromosome segregation and cell-survival regulation.
Biological function: BIRC5 encodes survivin, a single-BIR-domain member of the inhibitor of apoptosis protein family. Beyond regulation of apoptotic cell death, survivin is a component of mitotic chromosome-passenger machinery and contributes to accurate chromosome segregation and cytokinesis. Multiple transcript variants encode distinct isoforms.
