Anticorps primaire fourni par Boster Bio
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Le membre 11 de la famille Schlafen est une protéine qui, chez l'homme, est codée par le gène SLFN11. SLFN11 est une protéine nucléaire qui appartient à la famille de gènes Schlafen (SLFN) impliquée dans la régulation du cycle cellulaire et l'inhibition de la croissance. L'expression de SLFN11 prédit la sensibilité des lignées cellulaires cancéreuses aux agents endommageant l'ADN. Des preuves suggèrent qu'en présence de thérapies ciblant l'ADN, SLFN11 est recruté vers les fourches de réplication stressées où il bloque la réplication, entraînant la mort cellulaire. SLFN11 est exploré en tant que biomarqueur prédictif de la réponse aux thérapies ciblant l'ADN.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.