Anticorps primaire fourni par Boster Bio
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L'UCH-L1, également connu sous le nom de PGP9.5, est un membre d'une famille de gènes dont les produits hydrolysent de petits adduits d'ubiquitine à l'extrémité C-terminale pour générer le monomère d'ubiquitine. L'expression de l'UCH-L1 est très spécifique aux neurones et aux cellules du système neuroendocrinien diffus et de leurs tumeurs. Il est abondamment présent dans tous les neurones (représente 1 à 2 % des protéines cérébrales totales), exprimé spécifiquement dans les neurones et les testicules/ovaires. La triade catalytique de l'UCH-L1 contient une cystéine en position 90, un aspartate en position 176 et une histidine en position 161 qui sont responsables de son activité hydrolase.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Humain | ||||||||
| Souris | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
UCHL1 identifies ubiquitin C-terminal hydrolase L1 in Homo sapiens (Human). This target record connects NCBI Gene 7345, UniProtKB P09936 and related ABMIUM catalogue products.
Biological function: Ubiquitin C-terminal hydrolase L1 (UCHL1; PGP9.5) is a cysteine deubiquitinase/thiol protease that cleaves ubiquitin at its C-terminal glycine. It is strongly associated with neuronal and neuroendocrine cell biology.
