Anticorps primaire fourni par Boster Bio
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Ce gène code l'une des deux neuropilines, qui contiennent des domaines protéiques spécifiques leur permettant de participer à plusieurs types de voies de signalisation différentes qui contrôlent la migration cellulaire. Les neuropilines contiennent un grand domaine extracellulaire N-terminal, composé de domaines de liaison au complément, de facteur de coagulation V/VIII et de méprine. Ces protéines contiennent également un court domaine transmembranaire et un petit domaine cytoplasmique. Les neuropilines se lient à de nombreux ligands et à divers types de co-récepteurs ; elles affectent la survie, la migration et l'attraction cellulaires. Certains des ligands et co-récepteurs liés par les neuropilines sont le facteur de croissance endothélial vasculaire (VEGF) et les membres de la famille des sémaphorines. Plusieurs variants de transcription épissés alternativement qui codent différentes isoformes protéiques ont été décrits pour ce gène.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Humain | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
NRP1 identifies neuropilin 1 in Homo sapiens (Human). This target record connects NCBI Gene 8829, UniProtKB O14786 and related ABMIUM catalogue products.
Biological function: Neuropilin 1 (NRP1; neuropilin-1, CD304/BDCA4) is a transmembrane co-receptor that binds vascular endothelial growth factor and semaphorin-family ligands and modulates signalling involved in cell migration, survival, axon guidance and vascular development.
