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La NCAM est une glycoprotéine liée à la membrane qui joue un rôle dans l'adhésion cellule-cellule et cellule-matrice grâce à son activité de liaison homophile et hétérophile. La molécule d'adhérence cellulaire neurale apparaît sur les cellules embryonnaires précoces et est importante dans la formation des collectifs cellulaires et de leurs limites aux sites de morphogenèse. Plus tard dans le développement, elle est trouvée sur divers tissus différenciés et est une CAM majeure médiatisant l'adhérence entre les neurones et entre les neurones et les muscles. Le gène NCAM est cartographié sur 11q23. La molécule d'adhérence cellulaire neurale (NCAM) peut influencer un certain nombre d'événements intercellulaires divers, y compris la communication jonctionnelle, l'association des axones avec des voies et des cibles, et des signaux qui modifient les niveaux d'enzymes neurotransmettrices.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Humain | ||||||||
| Souris | ||||||||
| Rat |
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Neural cell adhesion molecule 1 (NCAM1), also known as NCAM and CD56, is a cell-adhesion glycoprotein with established roles in neural-cell interactions. This ABMIUM record connects NCBI Gene 4684 and UniProtKB P13591 to catalogue-backed research products.
Biological function: Neural cell adhesion molecule 1 (NCAM1/CD56) mediates cell-cell adhesion and contributes to neural development and plasticity. It is involved in neuron-neuron adhesion, neurite fasciculation and neurite outgrowth, with multiple isoforms supporting context-dependent cell interactions.
