Anticorps primaire fourni par Boster Bio
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MUTATED IN COLORECTAL CANCERS (MCC) est un gène suppresseur de tumeur. Il est situé sur 5q22.2. Ce gène supprime la prolifération cellulaire et la voie Wnt/bêta-caténine dans les cellules de cancer colorectal. MCC inhibe également la liaison à l'ADN des facteurs de transcription bêta-caténine/TCF/LEF, et il est impliqué dans la migration cellulaire indépendamment de l'activation de RAC1, CDC42 et de la kinase activée par p21 (PAK). De plus, MCC peut interagir avec SCRIB (via le motif de liaison PDZ phosphorylé), EZR, SNX27, SLC9A3R1 et SLC9A3R2.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Humain | ||||||||
| Souris | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.