Anticorps primaire fourni par Boster Bio
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L'interleukine-10 (IL-10 ou IL10), également connue sous le nom de facteur inhibiteur de la synthèse de cytokines humaines (CSIF), est une cytokine anti-inflammatoire. Chez l'homme, l'IL-10 est codée par le gène IL10. Elle est capable d'inhiber la synthèse de cytokines pro-inflammatoires telles que l'IFN-gamma, l'IL-2, l'IL-3, le TNFalpha et le GM-CSF produites par des cellules telles que les macrophages et les lymphocytes T régulateurs. L'IL-10 présente également de puissantes capacités à supprimer la capacité de présentation d'antigènes des cellules présentatrices d'antigènes. Kim et al. (1992) ont montré que le gène murin Il10 contient 5 exons et s'étend sur environ 5,2 kb d'ADN génomique. Eskdale et al. (1997) ont cartographié le gène IL10 à la jonction entre 1q31 et 1q32.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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IL10 identifies interleukin 10 in Homo sapiens (Human). This target record connects NCBI Gene 3586, UniProtKB P22301 and related ABMIUM catalogue products.
Biological function: IL10 is a major immune-regulatory cytokine with anti-inflammatory activity. Through the IL10RA and IL10RB receptor complex it activates JAK-STAT signalling, including STAT3, and suppresses production of multiple pro-inflammatory mediators by antigen-presenting cells.
