Anticorps primaire fourni par Boster Bio
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L'interleukine-10 (IL-10 ou IL10), également connue sous le nom de facteur inhibiteur de la synthèse des cytokines humaines (CSIF), est une cytokine anti-inflammatoire. Chez l'homme, l'IL-10 est codée par le gène IL10. Elle est capable d'inhiber la synthèse de cytokines pro-inflammatoires telles que l'IFN-gamma, l'IL-2, l'IL-3, le TNFalpha et le GM-CSF produites par des cellules telles que les macrophages et les lymphocytes T régulateurs. L'IL-10 présente également de puissantes capacités à supprimer la capacité de présentation d'antigènes des cellules présentatrices d'antigènes. Kim et al. (1992) ont montré que le gène IL 10 de la souris contient 5 exons et s'étend sur environ 5,2 kb d'ADN génomique. Eskdale et al. (1997) ont cartographié le gène IL10 à la jonction entre 1q31 et 1q32.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Souris | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
IL10 identifies interleukin 10 in Homo sapiens (Human). This target record connects NCBI Gene 3586, UniProtKB P22301 and related ABMIUM catalogue products.
Biological function: IL10 is a major immune-regulatory cytokine with anti-inflammatory activity. Through the IL10RA and IL10RB receptor complex it activates JAK-STAT signalling, including STAT3, and suppresses production of multiple pro-inflammatory mediators by antigen-presenting cells.
