Anticorps primaire fourni par Boster Bio
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La cGAS (cyclic GMP-AMP synthase), également connue sous le nom de MB21D1 (Mab-21 domain containing 1), h-cGAS ou C6orf150, est une nucléotidyltransférase cytoplasmique de 522 acides aminés qui catalyse la formation de GMP-AMP cyclique (cGAMP) à partir de l'ATP et du GTP. La cGAS est suggérée pour avoir une activité antivirale en agissant comme un capteur clé d'ADN cytosolique. La cGAS se lie à l'ADN cytosolique, ce qui conduit à la synthèse de cGAMP et à l'activation de TMEM173, déclenchant ainsi la production d'interféron de type I. Exprimée dans la lignée cellulaire monocytaire THP1, la cGAS existe sous forme de deux isoformes épissées alternativement et est codée par un gène situé sur le chromosome humain 6q13.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
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