Anticorps primaire fourni par Boster Bio
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L'antigène CD8 est une glycoprotéine de surface cellulaire présente sur la plupart des lymphocytes T cytotoxiques qui assure des interactions cellule-cellule efficaces au sein du système immunitaire. Il est cartographié sur 2p11.2. L'antigène CD8, agissant comme corécepteur, et le récepteur des cellules T sur le lymphocyte T reconnaissent l'antigène présenté par une cellule présentatrice d'antigène (APC) dans le contexte des molécules du CMH de classe I. Le corécepteur fonctionnel est soit un homodimère composé de deux chaînes alpha, soit un hétérodimère composé d'une chaîne alpha et d'une chaîne bêta. Les chaînes alpha et bêta partagent une homologie significative avec les chaînes légères variables des immunoglobulines. Ce gène code également pour les isoformes de la chaîne alpha CD8.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Souris | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
CD8 subunit alpha (CD8A), also known as CD8 alpha and T-cell surface glycoprotein CD8 alpha chain, is a T-cell coreceptor protein. This guide connects human NCBI Gene 925, UniProtKB P01732 and ABMIUM catalogue products associated with CD8A.
Biological function: CD8 alpha is a cell-surface glycoprotein expressed on many cytotoxic T lymphocytes and functions as a coreceptor with the T-cell receptor during recognition of antigen presented by MHC class I molecules. CD8A can form alpha-alpha homodimers or alpha-beta heterodimers with CD8B.
