Anticorps primaire fourni par Boster Bio
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L'ATF1, également connu sous le nom de facteur de transcription activateur 1, est une protéine qui, chez l'homme, est codée par le gène ATF1. Il est cartographié sur 12q13.12. Ce gène code un facteur de transcription activateur, qui appartient à la sous-famille ATF et à la famille bZIP (leucine zipper à région basique). Il influence les processus physiologiques cellulaires en régulant l'expression des gènes cibles en aval, qui sont liés à la croissance, à la survie et à d'autres activités cellulaires. Cette protéine est phosphorylée à la sérine 63 dans son domaine inductible par la kinase par les sérine/thréonine kinases, la protéine kinase A dépendante de l'AMPc, la protéine kinase I/II dépendante de la calmoduline, la protéine kinase activée par les mitogènes et le stress et la cycline-dépendante kinase 3 (cdk-3). Sa phosphorylation améliore ses activités de transactivation et transcriptionnelles, et améliore la transformation cellulaire.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Activating transcription factor 1 (ATF1), reviewed by UniProt as cyclic AMP-dependent transcription factor ATF-1, is a bZIP transcription factor that links cAMP/PKA signalling to CRE-dependent gene regulation. Human ATF1 maps to NCBI Gene 466 and reviewed UniProtKB P18846; this record links the verified target to related ABMIUM catalogue products.
Biological function: ATF1 binds cAMP response elements (CREs) in promoters and mediates PKA-responsive transcription. Phosphorylation within its kinase-inducible domain enhances transactivation, supporting stimulus-responsive regulation of gene expression.
