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L'aldolase A (ALDOA, ou ALDA), également connue sous le nom de fructose-bisphosphate aldolase, est une enzyme qui chez l'homme est codée par le gène ALDOA sur le chromosome 16. Ce gène code un membre de la famille des protéines fructose-bisphosphate aldolase de classe I. La protéine codée est une enzyme glycolytique qui catalyse la conversion réversible du fructose-1,6-bisphosphate en glycéraldéhyde 3-phosphate et en dihydroxyacétone phosphate. Trois isozymes d'aldolase (A, B et C), codées par trois gènes différents, sont exprimées différentiellement au cours du développement. Les mutations de ce gène ont été associées à la maladie de stockage du glycogène XII, un trouble autosomique récessif associé à l'anémie hémolytique. La perturbation de ce gène joue également un rôle dans la progression de plusieurs types de cancers. Des pseudogènes apparentés ont été identifiés sur les chromosomes 3 et 10.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Humain | ||||||||
| Souris | ||||||||
| Rat |
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ALDOA encodes aldolase, fructose-bisphosphate A; reviewed UniProt names the protein fructose-bisphosphate aldolase A. Also known as muscle-type aldolase, it is a class I glycolytic enzyme that reversibly cleaves fructose 1,6-bisphosphate into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate.
Biological function: Fructose-bisphosphate aldolase A catalyses a central reversible step in glycolysis and gluconeogenesis, interconverting fructose 1,6-bisphosphate with two triose phosphates. Reviewed UniProt also supports non-catalytic and scaffolding roles linked to metabolic responses to glucose availability.
