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Ce gène code un membre de la famille des protéines Argonaute, qui s'associent aux petits ARN et jouent un rôle important dans l'interférence ARN (ARNi) et le silençage de l'ARN. Cette protéine se lie aux microARN (miARN) ou aux petits ARN interférents (siARN) et réprime la traduction des ARNm qui leur sont complémentaires. Elle est également impliquée dans le silençage transcriptionnel des gènes (STG) des régions promotrices complémentaires aux petits ARN antigènes (agARN) liés, ainsi que dans la dégradation des cibles ARNm liées aux miARN. Des variants de transcrits épissés alternativement codant différentes isoformes ont été trouvés pour ce gène. Une étude récente a montré que ce gène est une cible authentique de lecture des codons stop, et que son ARNm pourrait donner naissance à une isoforme étendue C-terminale supplémentaire par l'utilisation d'un codon de terminaison de traduction alternatif en phase.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Humain | ||||||||
| Souris | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
AGO1 (argonaute RISC component 1; protein argonaute-1) is an Argonaute-family RNA-binding protein that uses small regulatory RNAs to guide gene silencing. It is studied as a core component of miRNA- and siRNA-associated post-transcriptional regulation.
Biological function: Protein argonaute-1 binds microRNAs (miRNAs) and small interfering RNAs (siRNAs) and uses their sequence information to recognize complementary RNA targets. AGO1 supports RNA interference and RNA silencing, including translational repression and degradation of miRNA-bound mRNA targets; NCBI also describes a role in transcriptional gene silencing of complementary promoter regions.
