Anticorps primaire fourni par Boster Bio
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ADAMTS5 (A Disintegrin-Like and Metalloproteinase with Thrombospondin Type 1 Motif, 5), est une enzyme qui chez l'homme est codée par le gène ADAMTS5. ADAMTS5 est un membre de la grande famille ADAMTS des protéases dépendantes du zinc. L'enzyme codée par ce gène contient deux motifs TS C-terminaux et fonctionne comme aggrecanase pour cliver l'aggrécan, un protéoglycane majeur du cartilage. Par analyse hybride de cellules somatiques, le gène humain ADAMTS5 est localisé sur le chromosome 21. Des modèles de souris ont montré que Sdc4 contrôle une voie qui active Adamts5 à la surface des chondrocytes via l'activation Erk1/Erk2 de Mmp3.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Espèce | WB | IHC | IHC-P | IHC-F | IF/ICC | Cytométrie en flux | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Humain | ||||||||
| Souris | ||||||||
| Rat |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.