Recombinant Human AITR Ligand/TNFSF18 protein

Background

AITR Ligand (activation-inducible TNF receptor superfamily member ligand) is also named GITR Ligand (glucocorticoid-induced tumor necrosis factor receptor ligand) and TNFRSF18, regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene codes for a type II transmembrane protein comprised of 177 amino acids, including a 28 amino acid cytoplasmic region, a 21 amino acid transmembrane domain and a 128 amino acid extracellular domain. Recombinant human AITRL is a 14.3 kDa protein, containing 126 amino acid residues corresponding to the extracellular domain of AITR Ligand.

Expression system

Escherichia coli.

Purity

> 98 % by SDS-PAGE and HPLC analyses.

Molecular weight

Approximately 14.3 kDa, a single non-glycosylated polypeptide chain containing 126 amino acids.

Endotoxin

Less than 0.1 EU/μg of rHuAITR Ligand/TNFSF18 as determined by LAL method.

Form

Sterile Filtered White lyophilized (freeze-dried) powder. Formulation Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH7.4.

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