Rat Anti-Mullerian Hormone, AMH ELISA Kit
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Anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting hormone (MIH), is a glycoprotein hormone structurally related to inhibin and activin from the transforming growth factor beta superfamily, whose key roles are in growth differentiation and folliculogenesis. In humans, the gene for AMH is AMH, on chromosome 19p13.3, while the gene AMHR2 codes for its receptor on chromosome 12. AMH is activated by SOX9 in the Sertoli cells of the male fetus. Its expression inhibits the development of the female reproductive tract, or Müllerian ducts (paramesonephric ducts), in the male embryo, thereby arresting the development of fallopian tubes, uterus, and upper vagina. AMH expression is critical to sex differentiation at a specific time during fetal development, and appears to be tightly regulated by nuclear receptor SF-1, transcription GATA factors, sex-reversal gene DAX1, and follicle-stimulating hormone (FSH). Mutations in both the AMH gene and the type II AMH receptor have been shown to cause the persistence of Müllerian derivatives in males that are otherwise normally masculinized.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants |
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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AMH (anti-Mullerian hormone; anti-Muellerian hormone) is a secreted TGF-beta-superfamily ligand also known as Mullerian-inhibiting substance (MIS). It signals through AMHR2 and downstream SMAD pathways in reproductive development and gonadal biology.
Biological function: AMH is synthesized as a preproprotein and proteolytically processed into an active ligand complex. It binds the type-II receptor AMHR2, which recruits type-I receptors including ACVR1 and BMPR1A to activate SMAD signalling. During male fetal development this pathway drives Mullerian duct regression; AMH also contributes to Leydig-cell and ovarian follicle biology.
