Human Ubiquitin-like Modifier-activating Enzyme Atg7, ATG7 ELISA Kit
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E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity).
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
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ATG7 (autophagy related 7) encodes ubiquitin-like modifier-activating enzyme ATG7, an E1-like enzyme that drives the ATG12-ATG5 and ATG8/LC3 conjugation systems required for autophagosome formation. ABMIUM catalogue products linked below target ATG7; suitability remains product- and application-specific.
Biological function: ATG7 acts as the E1-like activating enzyme for two core autophagy conjugation pathways. It activates ATG12 for conjugation to ATG5 and activates ATG8-family proteins for phosphatidylethanolamine conjugation, supporting LC3 lipidation and autophagosomal membrane formation. Reviewed UniProt also supports a role in mitophagy and mitochondrial quality control.
