Human Reticulon-4 Receptor, RTN4R ELISA Kit
Know who made it. See the evidence. Buy through one marketplace.
Receptor for RTN4, OMG and MAG (PubMed: 12037567, PubMed: 12068310, PubMed: 12426574, PubMed: 12089450, PubMed: 16712417, PubMed: 18411262, PubMed: 12839991, PubMed: 19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed: 18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed: 12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed: 16712417, PubMed: 22325200). Mediates axonal growth inhibition (PubMed: 12839991, PubMed: 19052207, PubMed: 28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed: 22325200).
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants | Ascites | Tissue homogenates |
|---|---|---|---|---|---|
| Compatibility |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
RTN4R identifies reticulon 4 receptor in Homo sapiens (Human). This target record connects NCBI Gene 65078, UniProtKB Q9BZR6 and related ABMIUM catalogue products.
