Mouse Allograft Inflammatory Factor 1, AIF1 ELISA Kit
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Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants | Ascites | Tissue homogenates |
|---|---|---|---|---|---|
| Compatibility |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
AIF1 is allograft inflammatory factor 1, widely recognised in research as IBA1 (ionized calcium-binding adapter molecule 1). It is a calcium- and actin-binding protein associated with myeloid-cell cytoskeletal responses and is commonly studied in macrophage and microglial biology.
Biological function: AIF1/IBA1 binds actin and calcium and contributes to cytoskeletal remodelling, membrane ruffling and cell motility. Reviewed evidence supports roles in RAC-dependent actin dynamics, phagocytic activity and macrophage activation, making AIF1 useful for investigating changes in myeloid-cell state and morphology.
