BCL2 Monoclonal Antibody
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This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | WB | FCM | ELISA |
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
BCL2 apoptosis regulator (BCL2; Bcl-2) is an anti-apoptotic mitochondrial membrane protein. This target guide connects human NCBI Gene 596, UniProtKB P10415 and ABMIUM catalogue products associated with BCL2.
Biological function: BCL2 apoptosis regulator, commonly called Bcl-2, suppresses programmed cell death in multiple cell systems and regulates apoptosis through effects on mitochondrial membrane permeability and cytochrome-c release. Its cell-survival role makes BCL2 a central target in apoptosis, mitochondrial signalling, lymphocyte biology and cancer research.
