AGRIN Polyclonal Antibody
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This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ)| as identified in mouse knock-out studies. The encoded protein contains several laminin G| Kazal type serine protease inhibitor| and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles| a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | WB | ELISA |
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Agrin (AGRN) is an extracellular matrix and synaptic organizer with a central role in neuromuscular junction formation and maintenance. This ABMIUM record links human AGRN (NCBI Gene 375790; reviewed UniProt O00468) to catalogue-backed research products.
Biological function: Agrin (AGRN) is a heparan-sulfate basal-lamina glycoprotein whose neuronal isoforms organize postsynaptic differentiation at the neuromuscular junction. Reviewed UniProt evidence describes AGRN-LRP4 complex formation, activation of MUSK and clustering of acetylcholine receptors, with additional isoform-dependent roles in neurite outgrowth and synapse biology.
