Probetacellulin Polyclonal Antibody
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BTC encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of betacellulin bind to multiple different EGF receptors. Betacellulin romotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in BTC may be associated with type 2 diabetes in human patients.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | WB | ELISA |
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| Applications |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
BTC (betacellulin) encodes probetacellulin, an EGF-family membrane precursor that can be proteolytically processed to soluble betacellulin. It is studied as an ERBB-family growth-factor ligand in cell proliferation and differentiation signalling.
Biological function: Probetacellulin is a single-pass membrane precursor whose processed betacellulin growth factor binds EGFR, ERBB4 and other EGF-receptor family members. Reviewed human evidence supports mitogenic activity, including effects on retinal pigment epithelial and vascular smooth-muscle cells.
